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Kumari and Gupta (2013) examined the antifungal properties of Catharanthus roseus against several clinically significant fungal strains namely; Fusarium moniliforme, Candida albicans, Aspergillus niger and Aspergillus fumigatus. Side effects limits its clinical use. The standard drug at a 50 mg/ml showed paralysis at 31.33 min and death time was 40.67 mins. It is also used for chest ailments.~ In Philippines, the leaves can be used for treating diabetes and stomach cramps while the root decoction is used for treating intestinal parasitism. Uses, Benefits, Cures, Side Effects, Nutrients in Catharanthus Roseus. The alkaloids may also offer sedative and tranquilizing properties. Furthermore, this plant can be quite toxic if excessively consumed orally thus only the recommended dosages should be consumed. The flowers are whitish in colour with a yellow midpoint and a basal tube that measures between 2.5 to 3 centimetres long. ~ In Malaysia, the plant is used for tackling hypertension, diabetes, cancer and insomnia. The plant grows approximately 1 metre tall while the oblong leaves grow between 2.5 to 9 centimetres long and 1 to 3.5 centimetres broad. Furthermore, the alkaloids isolated from rosy periwinkle contain tranquilising (soothing effect) and hypotensive (lowers the blood pressure) properties. The data showed that the pattern of inhibition is highly dependent on the extraction solvent. The root contains bornesitol, d-yohimbine ajmalicine, olenolic acid, alstonine and urosolic acid. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. It is popularly known as Madagascar periwinkle. (2011), Evaluation os Hypolipidemic activity of leaf juice of Catharanthus roseus (Linn.) The plant stems were soaked in dichloromethane (DCM) solution while three batches of rubber trees that consist of five trees were prepared. Another important anthocyanidin pigment found in the flowers of rose periwinkle is rosinidin. Decoctions of the plant have been used to treat ocular inflammation, diabetes, hemorrhages, insect stings, and cancers.2, 4, 5, 6, 7 Zaini and Halimoon (2013) reported that the white root disease caused by the Rigidoporus Microporus fungus are the most destructive disease found in a rubber plantation. One such plant is Catharanthus roseus which is easily available and enjoys a very good reputation in indigenous medicine. The alkaloids are prescribed in anticancer therapy, usually as part of complex chemotherapy protocols. Results indicate increased metabolization of glucose in treated rats. Other traditional herbal treatments include using the plant for … Remarkably, vinblastine and vincristine isolated from this plant … Catharanthus roseus (Vinca) Medicinal plant benefits and images. Adult guinea pigs of either sex were divided into 7 groups. ~ In India, the leaves extracts are applied on the skin for numbing and neutralising bee sting/ wasp sting. Catharanthus roseus Leaves as an Anti- diabetic and Hypolipidemic Agents in Alloxan- Induced Diabetic Rats / Leena Muralidharan* / AJPC(2)(12)(2014) 1393-1396 (39) Comparative studies of elemental composition in leaves and flowers of Catharanthus roseusgrowing in Bangladesh / Shahin Aziz, Koushik Saha, Nasim Sultana, Husna Parvin Nur, Md. In parts of Central America, it is made into a gargle for sore throats. Other herbs for treating diabetes can be found. Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). The results support the antibacterial and antidiabetic efficacy of the extract thus can be used not only for treating infections but also for treating diabetes. Description. Vol 2, Issue 3, pp. 9. Piperazine citrate was used as the standard reference. Ibrahim et al., (2011), evaluated the antibacterial and antidiabetic activities of Catharanthus roseus extracts. It has been used in traditional medicine for thousands of years for treating various diseases and especially it is very famous for it’s use in treating diabetics. It is M phase cell cycle-specific and is an integral component of a plethora of chemo-therapy regimens, including ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) for Hodgkin’s lymphoma. Other herbs for treating diabetes can be found here. (2014), Antioxidant activity and phytochemical analysis of fractionated leaf extracts of Catharanthus roseus, International Journal of Pharmacognosy, vol. Published on Mar 20, 2020 PINK PERIWINKLE | Catharanthus roseus is known as ‘tsitsirika’ in the Philippines. These daily supplements have also been deemed effective for preventing and inhibiting the abnormal coagulation of blood in the brain. This was followed by treating the diabetic rats with the extract (500mg/kg body weight) daily for 14 consecutive days. Share. Herbal use in the Caribbean includes using extracts from the flowers as an eyewash for infants. The results support the antibacterial and antidiabetic efficacy of the extract thus can be used not only for treating infections but also for treating diabetes. The oval, hairless, greenish leaves are glossy in appearance with a short petiole that measures between 1 to 1.8 centimetres long. The antibacterial activity was performed using seven different gram positive and gram negative bacterial strains.The extract was reported to contain significant antibacterial action against all the bacterial strains. Scientists discovered the presence of several highly toxic alkaloids in the tissues of C roseus, while researching the anti-diabetic properties of the plant. The plant grows approximately 1 metre tall while the oblong leaves grow between 2.5 to 9 centimetres long and 1 to 3.5 centimetres broad. Interestingly, most of these medicinal plants are capable of attacking fungal, bacterial and viral infections. 6, pp. The aerial parts of the plant are used for the extraction of the medicinal alkaloids vincristine and vinblastine. The results support that vincamine has more effects and is superior to placebo in patients with mild to moderate dementia. This suggests why vinblastine is used for treating neoplasms (a new and abnormal growth of tissue in the body parts) choriocarcinoma (a fast-growing type of cancer that occurs in a woman's uterus (womb) and Hodgkin’s disease (painless enlargement of the lymph nodes, liver, and spleen). 500 ml of the extracts were used as biofungicides against white root disease. 9.7] Nayak B. S., Anderson M. and Pereira L. M. P. (2007), Evaluation of wound-healing potential of Catharanthus roseus leaf extract in rats. 1] Agarwal, S., Jacob, S., Chettri, N., Bisoyi, S., Tazeen, A., Vedamurthy, A. ~ In Madagascar, the leaves are used as vomitive (inducing vomiting), the roots are used as purgative, anthelmintic (for expelling worms), hemostatic (causes bleeding to stop) and for stopping toothache. Vincristine is mostly sold as oncovin. Catharanthus roseus is one plant recognized well in Ayurveda. The stem extracts of kemunting cina were antagonistic and inhibited the Rigidoporus microporus fungus. Nayak et al., (2007) carried out an experiment where rats were treated with 100 mg /kg/day of the Catharanthus roseus ethanol extract. The leaves can also be infused and used for treating menorrhagia (abnormally heavy bleeding at menstruation). Despite serious safety concerns, periwinkle is used for “brain health” (increasing blood circulation in the brain, supporting brain metabolism, increasing mental productivity, preventing memory and concentration problems and feebleness, improving memory and thinking ability, and preventing early aging of brain cells). Anti-microbial PropertiesPrajakta et al., (2010) investigated some of the antimicrobial properties of the rosy periwinkle plant. ~ In Jamaica and Cuba, the flower extracts are used as an eyewash for infants. However, only 142 patients completed the trial. The antimicrobial activity was also checked against microorganisms such as Salmonella typhimurium NCIM 2501, Pseudomonas aeruginosa NCIM 2036 and Staphylococcus aureus NCIM 5021. The rosy periwinkle extracts and the fractions contained significant levels of antioxidants at various concentrations.The leaves demonstrated good antioxidant effects of 81.70%. 2.Catharanthus Roseus Extract increases blood flow to the brain. List of various diseases cured by Catharanthus Roseus. Therefore the results show that the ethanol extract of Catharanthus roseus has significant anthelmintic properties against Pheretima posthuma. According to Jaleel et al., (2009) the anticancer alkaloids (vinblastine and vincristine) found in the leaf and stem of Catharanthus roseus inhibits cancer and tumour cells in the body. These treated rats recorded high rate of wound contraction that significantly reduced the epithelization (process of covering a denuded surface with epithelium) period. The organic extracts demonstrated more significant antifungal activity, unlike the aqueous extracts. 152 male and female patients aged between 50 and 85 years from two psychogeriatric centres and two nursing homes were initially included in the trial and screened for eligibility. The impacts of the extract on the biochemical parameters such as urea, creatinine, alkaline phosphatase and total cholesterol were also measured. To. The examination was carried out using paper disc diffusion method whereby 3 extraction media (acetone, aqueous and ethanol) were used.The data showed that the pattern of inhibition is highly dependent on the extraction solvent. Catharanthus roseus is a small upright shrub prized for its shining green leaves and delicate looking flower. Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). 4] Ethalsha, P. and Retna, A. M. (2014), Evaluation of antioxidant potential and antibacterial activity of crude extracts Catharanthus roseus, International journal of Pharmaceutical sciences and research, vol. How Catharanthus Roseus is effective for various diseases is listed in repertory format. 5, issue, 8, pp. It is small in size perennial herbaceous evergreen plant that was native to the Madagascar island. Therefore the results show that the ethanol extract of Catharanthus roseus has significant anthelmintic properties against Pheretima posthuma. Furthermore, Quideau et al., (2011) attested that the main active substances in plants are alkaloids, phenolic acids and flavonoids. C. roseus has been introduced into new habitats worldwide mostly to be used as an ornamental and a medicinal plant. Pharm Biol. Nat Prod 50:586–621. The fruit is a pair of follicles that measures approximately 3 millimetres broad and 2 to 4 centimetres long. There are several ways you can get this benefit from the periwinkle flowers. Despite serious safety concerns, periwinkle is used for “brain health” (increasing blood circulation in the brain, supporting brain metabolism, increasing mental productivity, preventing memory and concentration problems and feebleness, improving memory and thinking ability, and preventing early aging of brain … 6, pp. The glucose level reduced while the body weight was increased in extract treated and standard treated groups when compared to the diabetic group. It is popularly known as Madagascar periwinkle. Adult guinea pigs of either sex were divided into 7 groups. (2011), Evaluation os Hypolipidemic activity of leaf juice of Catharanthus roseus (Linn.) Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). Recent years have seen nanotechnology-based synthesis, and these formulations have been considered to increase the efficacy of the bioactive compounds. Catharanthus roseus (L.) G. Don Show All Show Tabs Madagascar periwinkle General Information; Symbol: CARO14 Group: Dicot Family: Apocynaceae Duration: Annual Perennial: Growth Habit: Forb/herb Subshrub: Native Status: HI I L48 I NAV I PB I PR I VI I: Data … Other plants for treating dementia can be found here.Anti-cancer PropertiesAccording to Jaleel et al., (2009) the anticancer alkaloids (vinblastine and vincristine) found in the leaf and stem of Catharanthus roseus inhibits cancer and tumour cells in the body. The flowers are pollinated by Butterflies. These were assessed for DPPH (diphenylpicrylhydrazyl) radical scavenging activity. The data on tolerance and on therapy response were evaluated using descriptive statistics. Ibrahim et al., (2011), evaluated the antibacterial and antidiabetic activities of Catharanthus roseus extracts. Subject. The results were compared with the standard drug glibenclamide (5 mg/kg body weight) by measuring the glucose levels and the body weights of all the study animals. Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). In the experiment, group A was the control group, Group B consists of trees that were planted with fungus while Group C consists of trees that were applied with the stems extract together with the fungus. The results show that C. roseus extracts and fractions are an excellent source of natural antioxidants and could be utilised as a functional food or used for nutraceutical purposes. According to Ethalsha and Retna (2014), periwinkle contains more than 400 alkaloids of which some have been categorised as antineoplastic agents for inhibiting or preventing the growth and spread of tumours or malignant cells such as rhabdomyosarcoma, leukaemia, neuroblastoma, malignant lymphomas and Hodgkin's disease. Patel et al., (2011) evaluated the hypolipidemic activity of the rosy periwinkle leaf juice in normal and hyperlipidemic guinea pigs and its possible implication in managing metabolic syndrome (hyperlipidemia, hypertension and diabetes mellitus). The organic extracts demonstrated more significant antifungal activity, unlike the aqueous extracts. It is native and endemic to Madagascar, but grown elsewhere as an ornamental and medicinal plant, a source of the drugs vincristine and vinblastine, used to treat cancer. The therapeutic efficacy of vincamine was evidenced by the confirmatory analysis because the drug was statistically significantly superior to placebo in all the four target variables. 9] Patel, Y., Vadgama, V., Baxi, S. and Tripathi, C. B. These alkaloids are now used in the treatment of a number of different types of cancer. It is known for its antitumour, anti-diabetic, anti-microbial, anti-oxidant and anti-mutagenic effects. Patel et al., (2011) evaluated the hypolipidemic activity of the rosy periwinkle leaf juice in normal and hyperlipidemic guinea pigs and its possible implication in managing metabolic syndrome (hyperlipidemia, hypertension and diabetes mellitus). Fischhof et al., (1996) investigated the therapeutic effects of vincamine for treating primary degenerative and vascular dementia. Message The user has shared this species … Furthermore, this plant can be quite toxic if excessively consumed orally thus only the recommended dosages should be consumed. 165-173. Don't confuse periwinkle with Madagascar periwinkle (Catharanthus roseus). According to Zaini and Halimoon (2013), Catharanthus roseus is regarded as a poisonous plant because of the presence of danvinrosidin, catharanthine, vindolinine, leurosine, akuammine, norharman, lochnerine, vinleurosin, tetrahydroalstonine, vindoline and vincamine in it. The parts that grow above the ground are used to make medicine. Catharanthus roseus (L.) G. Don Show All Show Tabs Madagascar periwinkle General Information; Symbol: CARO14 Group: Dicot Family: Apocynaceae Duration: Annual Perennial: Growth Habit: Forb/herb Subshrub: Native Status: HI I L48 I NAV I PB I PR I VI I: Data … Catharanthus roseus is a tropical hardy plant grown as a pot ornamental plant for its rosy or white flowers. Catharanthus roseus (Vinca) also known as the Madagascar periwinkle or rosy periwinkle or Sadabahar is grown as an ornamental plant in the garden. It is also used for chest ailments. The parts that grow above the ground are used to make medicine. Sadabahar also known as Madagascar Periwinkle, “Sada Pushpa” belongs to the Apocynaceae family.It is called botanically as Catharanthus roseus. Hypolipidemic PropertiesCardiovascular disease (CVD) has been classified as the most common cause of death all over the world. The study supports the antibacterial efficacy of the Catharanthus roseus. Vinblastine is mostly sold as Velban. Among all the extracts, only the chloroform extract showed to be the most active against almost all the bacterial species tested. Corpus ID: 38654981. One such plant is Catharanthus roseus which is easily available and enjoys a very good reputation in indigenous medicine. Periwinkle [Catharanthus roseus (L) G. Don] has become one of the very extensively investigated medicinal plants after the discovery of two powerful anti-cancer alkaloids, vinblastine and vincristine, in its leaves more than 50 years ago.These alkaloidal drugs are still in clinical use. Despite serious safety … 29-35. They also help to increase the levels of serotonin (a compound found in serum and blood platelets that contracts the blood vessels and acts as a neurotransmitter) in the brain. 3490-3495.5] Fischhof P. K., Moslinger-Gehmayr R., Herrmann W. M., Friedmann A. and Russmann D. L. (1996), Theraupetic efficacy of Vincamine in dementia. 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